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MARCH 10, 2025

Perioperative Management of Patients Exposed to Hallucinogens and Psychedelics

It’s Time to Talk About ‘Magic Mushrooms’


PHILADELPHIA—When thinking about the effects of recreational substance use in patients undergoing anesthesia, some specific substances like cannabis may come to mind. Hallucinogens and psychedelics? Not so much, but perhaps they should.

Patients who use them may be at risk for serotonin syndrome if exposed to other serotonergic agents, whether a prescription antidepressant or postoperative opioids, according to a presentation at the 2024 annual meeting of the American Society of