—By David Holtzman
Researchers might have found a new link to Clostridioides difficile (formerly Clostridium difficile): the use of nonsteroidal anti-inflammatory drugs (NSAIDs).
Antibiotics, which disturb the gut microbiome, have always taken the blame for this highly prevalent nosocomial infection. But new findings in an animal model provide evidence for the NSAID connection, while describing a potential biological mechanism (mBio [Epub Jan 8, 2019]. doi: 10.1128/mBio.02282-18).