IV Vitamin C, Ozone Shown Effective Against COVID-19
“Vitamin C has a long track record,” said co-author Peter Papadakos, MD, FCCM, FAARC, the director of critical care medicine at the University of Rochester Medical Center and a professor of anesthesiology, surgery, neurosurgery and neurology at the University of Rochester, in New York. As an example, he and his colleagues have been using vitamin C for its anti-inflammatory effects and for fluid modulating purposes in severe burn patients for many years. Others have used vitamin C to treat sepsis and acute respiratory distress syndrome.
“With the global pandemic of COVID-19, we thought vitamin C would be an ideal agent to use in these patients,” Dr. Papadakos said. “Vitamin C has immunomodulating activity and reduces alveolar epithelial water in burns. It also has a very good safety profile.”
For IV administration of vitamin C, Dr. Papadakos recommended doses typically ranging from 0.2 to 0.5 g, whereas central venous access is preferred for very high doses, sometimes over 50 g/d (Table 1).
|Table 1. Protocol for IV Vitamin C Administration for COVID-19 Infection|
1 Caution with doses and frequency of administration.
2 If patient is in critical condition, suggest dose administration twice a day (every 12 hours).
3 220 mg of zinc sulfate contains 50 mg of elemental zinc.
4 Aim for 25(OH) level of 80-90 nmol/L.
Other components are added to the IV solution, if possible: zinc sulfate (200 mg over 24 hours), thiamine (400 mg daily), vitamin D (5,000-10,000 IU over 24 hours), and vitamin E (1,600 IU over 48 hours).
“All of these elements have been shown to be helpful,” Dr. Papadakos said. Treatment can also be supplemented with calcium and magnesium by IV, if necessary.
Ozone Disrupts Coronavirus
As a treatment, ozone attacks the envelope of coronaviruses, according to Dr. Papadakos. “By affecting cysteine, ozone disrupts viral proteins, lipoproteins, lipids and glycolipids in the actual virus. As a result, ozone creates a dysfunctional virus, which cannot replicate.” Ozone therapy also affects certain coagulation parameters.
To prepare ozone for IV, the patient’s blood is saturated with ozone from a medically approved ozone machine, then the patient’s blood containing the ozone molecule is infused into the patient (Table 2).
|Table 2. Ozone Autohemotherapy Protocol For COVID-19 Infection|
Peripheral venous access is favored, using a butterfly infusion set or cannula. The ozone/oxygen mixture is adjusted to a 1:1 ratio, with a starting dose of 25 mcg/mL of blood, followed in subsequent days by up to 80 mcg/mL.
The combination IV therapy begins with vitamin C at an intermittent infusion time of usually one to four hours, depending on the dose, followed by one to four hours of ozone, and then repeating the protocol over a few days.
“Because many COVID-19 patients require intubation, anything we can do to prevent intubation will greatly lessen the health care burden,” Dr. Papadakos said. “Part of the surge that hospitals are experiencing is from patients being intubated, which leads to mechanical ventilation for 10 to 15 days. That ties up the technology. Thus, anything we can do to try to decrease that initial inflammatory response and prevent the patient from being intubated in the first place helps not only the patient, but mitigates the surge as well. Our proposed synergistic therapy allows COVID-19 to become a more treatable disease.”